ISOLATION AND CHARACTERIZATION OF 9,12,15-OCTADECATRIENOIC ACID FROM THE DE-FATTENED SEEDS OF CHENOPODIUM AMBROSIOIDES LINN

A M Lohdip, C O Kelechi, M M Ekwenchi, S Yakubu

Abstract


 The de-fattened seed powder of Chenopodium ambrosioides  Linn was extracted twice using n-hexane after which

the urea and thiourea adduction was carried out using saturated urea in acetone and saturated thiourea in methanol

respectively. Gas chromatography- mass spectrometry (GC-MS) analysis was performed on adducts. The GC-MS

analysis showed that the urea adducts were straight chain compounds, while the thiourea adducts were branched

and cyclic compounds.The compound, 9,12,15-Octadecatrienoic acid was among the compounds detected from

the seeds of C. ambrosioides  Linn.for the first time. The adducts and non-adducts obtained was also tested for

antimicrobial activity on Escherichia coli, Staphylococcus aureus, Candida albicans  and Salmonella SP . There

was activity on Staphylococcus aureus  while a slight activity was observed in Candida albicans  but no activity

on Salmonella SP  and Escherichia coli .thiourea non-adduct showed more activity.

Key words:Chenopodium amnbrosioides , Urea, thiourea adduction, antimicrobial.


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